Indole-3-carbinol (I3C) is a compound found in high concentrations in vegetables of the Brassica family, including broccoli, cauliflower, Brussels sprouts, and cabbage.
As a dietary supplement, I3C provides key nutritional support for liver detoxification. It also plays an important role in supporting female reproductive health. The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM), which is thought to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.
In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen. The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.
Preliminary studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
Take 1 capsule one to two times daily or as recommended by a health-care practitioner.
Female patients who are prone to headaches and continue to have hot flashes and nightsweats on Estrogen replacement have found that if they take DIM (Indole-3-Carbinol / Diindolylmethane (DIM)complex) at the same time they take their Estradiol or Biest, they NO longer have hot flashes, sweats and headaches.
This may be due to I3C and DIM increasing C2 Hydroxylation of the estrogen in favor of C4 and C16 Hydroxylation which also decreases breast cancer risk.
If you are continuing to have these menopause symptoms while on Bio-Identical Estrogen therapy, try taking Indole 3 Carbinol by Thorne.
One Capsule Contains:
Indole-3-Carbinol / Diindolylmethane (DIM) complex 200 mg.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
This product does not contain wheat, gluten, corn, yeast, soy, egg, dairy products, or artificial colors, sweeteners, or flavors. This product also does not contain lactose, palmitic acid, or magnesium, calcium, or vegetable stearates.
If pregnant, consult your health-care practitioner before using this product.
There are no known adverse interactions or contraindications at publication date.