Female patients who are prone to headaches and continue to have hot flashes and night sweats on Estrogen replacement have found that if they take DIM (Indole-3-Carbinol / Diindolylmethane (DIM)complex) at the same time they take their Estradiol or Biest, they NO longer have hot flashes, sweats and headaches. This may be due to I3C and DIM increasing C2 Hydroxylation of the estrogen in favor of C4 and C16 Hydroxylation which also decreases breast cancer risk. If you are continuing to have these menopause symptoms while on Bio-Identical Estrogen therapy, try taking Indole 3 Carbinol.
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