Arginine & Citrulline Technical Sheet
ROLE AS NUTRIENT/FUNCTION
L-arginine is a conditional amino acid involved in many important
physiological processes including urea metabolism and excretion, DNA
synthesis, protein production, oxidative defense and hormone secretion. Arginine is also a nitric oxide (NO) precursor; its role in this process will be detailed here.
NO is synthesized using arginine and oxygen via various nitric oxide
synthase enzymes. NO generated from L-arginine is a highly reactive gas and an important messenger molecule that is involved in functions as diverse as neurotransmission, vasodilation, biological stress regulation, and modulation of gene expression. At low concentrations, NO produced in the blood vessel wall (endothelium) also mediates several biological processes such as vasodilation, platelet activation, regulation of monocyte and leukocyte adhesion, regulation ofsmooth muscle cell proliferation and the control of vascular oxidative stress, as well as the expression of redoxregulated
genes.
Citrulline is a non-essential amino acid which derives its name from
Citrullus vulgaris (watermelon). Citrulline is an immediate precursor for arginine. While it is involved in many physiological functions in the body, it is the main endogenous source of arginine and is an essential part of the urea cycle which rids the body of toxic ammonia.
Citrulline is also involved in the maintenance of muscle protein synthesis and supports a healthy nitrogen balance.
Take 1 capsule 2 times daily, or as directed by your healthcare practitioner.
Store in a cool, dry, dark place after opening.
Supplement Facts
Serving Size: 1 Veg Capsule
Servings Per Container: 120
L-Arginine (Free-Form) Amount per Serving 500 mg
L-Citrulline (Free-Form) Amount per Serving 250 mg
Other Ingredients: Hypromellose (cellulose capsule), Silicon Dioxide, Stearic Acid (vegetable source), Calcium Citrate and Microcrystalline Cellulose.
Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Caution: For adults only. Consult physician if pregnant/nursing, taking medication (especially antihypertensives, nitrates, or other heart medications), or have a medical condition (especially herpes, kidney impairment and/or glaucoma). Keep out of reach of children.
Natural color variation may occur in this product.
Store in a cool, dry, dark place after opening.
Cautions / Interactions:
For adults only.
Consult your healthcare practitioner if pregnant/nursing, taking medication (especially antihypertensives, nitrates, or other heart medications), or have a medical condition (especially herpes, kidney impairment and/or glaucoma).
Keep out of reach of children.
