DHEA is a natural steroid hormone that is synthesized from cholesterol through pregnenolone by the adrenal glands. DHEA acts as the parent precursor for other important steroid hormones, such as estradiol and other estrogens, and testosterone. While not a precursor to progesterone, DHEA made by the body can indirectly influence progesterone synthesis through a feedback mechanism whereby pregnenolone is converted to progesterone based on DHEA levels. Apart from these functions, DHEA also has important biological functions itself. Recent experimental and human studies show that DHEA is involved in supporting a large variety of physiological processes including immune function, brain function, bone metabolism, and the regulation of insulin-like growth factor levels. DHEA and its metabolite, DHEA sulfate, are present in human adult plasma in concentrations of 0.01-0.02 µM and 5 to 7 µM, respectively. DHEA sulfate levels are low in early childhood and begin to rise after age 7, peak at age 20-24, and then drop at a rate of approximately 20% per decade, until at age 85-90, levels are 10-15% of those at age 20-30. DHEA levels also decline under a variety of conditions of physiological stress. Vegetarians also have been shown to have decreased DHEA levels due to higher dietary fiber intake. ‡
SUGGESTED USE
Use 1 daily or as directed by your healthcare professional.
Supplement Facts
Amount Per Serving
Serving Size 1 Tablet
DHEA (dehydroepiandrosterone, micronized)25 mg
Other ingredients: Mannitol, microcrystalline cellulose, vegetable stearate and silica
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
Caution Athletes:
DHEA is classified as a prohibited substance by certain sports organizations, as well as the World Anti-Doping Association (WADA). Please consult the rules of your specific organization to determine if DHEA is prohibited.
SIDE EFFECTS
DHEA is SAFE for most people. It can cause some side effects including acne, hair loss, stomach upset, and high blood pressure. Some women can have changes in menstrual cycle, facial hair growth, and rarely a deeper voice after taking DHEA (Dr. Adrian has never seen this).
DHEA is POSSIBLY UNSAFE when used in larger amounts and long-term. Do not use DHEA in doses higher than recommended. Using higher doses or long-term use of DHEA can increase the chance of side effects.
Caution Athletes: DHEA is classified as a prohibited substance by certain sports organizations, as well as the World Anti-Doping Association (WADA). Please consult the rules of your specific organization to determine if DHEA is prohibited.
Special Precautions and WARNINGS
- Pregnancy and breast-feeding: DHEA is POSSIBLY UNSAFE when taken by mouth during pregnancy or breast-feeding. It can cause higher than normal levels of a male hormone called androgen. This might be harmful to the baby. Don't use DHEA if you are pregnant or breast-feeding. Note: DHEA can dramatically increase fertility for infertile women.
- Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: DHEA is a hormone that can affect how estrogen works in the body. If you have any condition that might be made worse by exposure to estrogen, don't use DHEA. (Dr. Adrian has never measured an appreciable increase in estrogen from DHEA).
- Liver problems: DHEA might make liver problems worse. This is likely a myth. A study discussed on PubMed.gov shows DHEA increased liver regeneration dramatically...read more
- Diabetes: DHEA can affect how insulin works in the body. If you have diabetes, monitor your blood sugar carefully if you are taking DHEA. You will likely need less insulin.
- Depression and mood disorders: There is some concern that patients with a history of depression and bipolar disorder might have some mental side effects if they use DHEA. DHEA can cause mania (excitability and impulsiveness), irritability, and sexual inappropriateness in people with mood disorders. If you have a mood disorder, be sure to discuss DHEA with your healthcare provider before you start taking it. Also, pay attention to any changes in how you feel. DHEA for many improves their mood and libido.
- Polycystic ovary syndrome (PCOS): Taking DHEA might make this condition worse. Don't use DHEA if you have PCOS. This warning is based upon the fact that high DHEA-S is a marker for PCOS. However, PCOS is caused partly by insulin resistance, a condition that DHEA helps.
- Cholesterol problems: DHEA might lower "good cholesterol" (high lipoprotein cholesterol, HDL). If your HDL level is already too low, discuss DHEA with your healthcare provider before you start taking it. Despite this warning, DHEA has been shown to decrease blocked arteries (atherosclerosis) in animal studies... read more
Possible side effects:
- include changes in liver function, acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other symptoms.
