NiaCel 400 is advanced support for cellular health and promote NAD+ production.* Designed for athletes and those in need of additional NR supplementation.
Lack of sleep, being stuck at a desk, too many late nights, over-exposure to the sun, and an unbalanced diet – each of these healthy lifestyle obstacles can affect your body at the cellular level, leading to depletion of NAD+ and the symptoms of early aging. The Nicotinamide Riboside (NR) in Thorne’s NiaCel 400 helps your body defend against these stressors by boosting the body’s production of NAD+, thus supporting healthy aging, optimal cellular metabolism, desired body composition, and athletic performance.*
NAD+ – nicotinamide adenine dinucleotide – is a coenzyme found in every cell. As a key coenzyme, NAD+ plays an integral role in multiple body functions, including DNA repair, cellular repair, energy production in the mitochondria, up-regulating the sirtuin proteins, gene expression, and cellular communication.* Not only do daily stresses of life contribute to the depletion of NAD+, the body’s natural level of NAD+ begins to significantly decline with age. A decreased level of NAD+ can begin to slow down vital bodily functions, resulting in many of the adverse symptoms of aging and age-related conditions.
High performance athletes experience aging at a different rate, which requires advanced nutritional support. Supplementing with Thorne’s NiaCel 400 provides advanced cellular support and enhances NAD+ production for athletes and individuals who require targeted clinical support.*
Benefits of Thorne’s NiaCel 400:
In addition to the benefits of NiaCel 200, Thorne’s NiaCel 400 offers advanced support for specific health concerns.*
- NiaCel 400 supports healthy heart function*
- NiaCel 400 provides neurological system support*
- NiaCel 400 supports healthy cellular repair*
- NiaCel 400 promotes optimal energy production in the mitochondria*
- NiaCel 400 promotes youthful-like cellular metabolism as a person ages*
- The betaine in NiaCel 400 promotes optimal methylation*
- NiaCel 400 boosts NAD+ production*
- NiaCel 400 supports normal circadian rhythm function*
Take an inside look at NiaCel 400’s two premier healthy-aging ingredients:
Nicotinamide Riboside Hydrogen Malate (NR)
As a direct precursor to NAD+, NR efficiently stimulates the production of NAD+, which:
- Promotes multiple aspects of healthy aging*
- Supports cellular repair processes*
- Protects against DNA damage and oxidative stress*
- Supports exercise efficiency, helping to support health and fitness goals*
- Helps maintain an optimal state of health*
- Supports the number and health of the mitochondria in cells, benefiting mitochondrial metabolism*
- Up-regulates the activity of the sirtuin proteins – which support numerous functions associated with healthy aging and cellular metabolism*
Betaine
To achieve NR’s optimal benefit, it is important to support the process of methylation. Betaine is a premiere methyl donor, meaning:
- Betaine (also called trimethylglycine) is a superior nutrient for donating its methyl groups – necessary compounds that help produce healthy DNA, neurotransmitters, and cellular energy.*
- In female athletes, research indicates that betaine promotes lean body composition by helping to reduce body fat without negatively affecting muscle mass.*
- Betaine supports the body’s ability to engage in higher volume exercise – increased repetitions and weight load in male athletes and improved high volume work capacity in female athletes.*
Other Information:
The U.S. Food and Drug Administration (FDA) recently declared that nicotinamide mononucleotide (NMN) is not a permissible dietary ingredient that can be used in dietary supplements to support NAD levels. As a result, on February 16, Amazon gave notice they will be removing all NMN-containing products from their online platform. Amazon’s cutoff will become final on March 13, 2023. Following Amazon’s lead, more and more groups will also likely remove NMN from their platforms. The resulting consequence is that many of you and your patients will be without an NAD support solution if you have previously been using NMN in your protocols and practice. If this is your situation, then I would recommend that you evaluate Thorne’s nicotinamide riboside salt, hydrogen malate, as your replacement ingredient for NAD support.
The Science
When looking at the literature regarding NMN, the original, preclinical work did look promising. Studies appeared to demonstrate support for NAD formation through the same salvage pathway as nicotinamide riboside (NR), and potentially more effectively because NR must be converted to NMN in the cell to make NAD. The literature suggested there was a potential for NMN to be directly brought into the cell. However, given the nucleotide structure, critics of this hypothesis have pointed out both stability limitations and limitations in NMN’s direct cellular absorption potential. Without either converting back to NR, or have other intermediates play a role, NMN might not be effectively absorbed by the cell.
A recent paper analyzing NMN in healthy middle-aged adults was conducted using three different doses of NMN – 300, 600, and 900 mg per day. The study showed there is a significant change in blood NAD levels over the course of 30 and 60 days of supplementation. At first blush, this result might appear to be the very evidence needed to demonstrate that NMN in human systems does raise NAD levels. However, let’s take a closer look. In the study, we do note there is a dose-dependent change in NAD levels from 300 mg to 600 mg. However, at the 900 mg dose there is no significant difference between the lower 600 mg dose, and, in fact, we see nearly identical changes in NAD levels over time for both the 600 mg and 900 mg doses, demonstrating a steep dose-saturation effect. It is also important to note that the study showed the highest significant change in NAD from baseline was roughly 40nM. On the other hand, when looking at similar blood data for changes in NAD levels with NR, we see a drastic difference in both NAD levels and in the dose-response curve. In acute dosing, as well as long-term dosing, we see a similar dose-response curve that does not saturate even at levels greater than 1,000 mg. We also observe that similar doses of NR (1,000 mg NR versus 900 mg NMN) show a far greater dose-response, with changes in NAD levels more than 40,000nM from baseline with NR versus the 40nM from baseline shown in the most recent NMN research.
So, what does this mean? Well, it would appear there is a step between the cell’s utilization of NMN within the salvage pathway, meaning NMN is not directly utilized by the cell. If it were, then we would expect to see a larger response to NMN supplementation on NAD levels at lower doses, which is actually quite the opposite from what is seen in the overall literature.
The Safety
Prior to the FDA’s recent denial of dietary ingredient status to NMN, there was a previous effort to establish NMN as a New Dietary Ingredient (NDI). The FDA’s response to NMN’s NDI petition was that there was only limited information to conclude, at that time, that NMN could demonstrate sufficient safety to be given NDI status. In contrast, in the marketplace today NR has achieved substantial safety reviews, all of which have shown that at current supplementation levels, NR is safe. The main difference between NR’s salt form options is that dosing utilizing the malate salt has been shown to be safe at higher doses than has been demonstrated by the chloride counterparts.
The Better Choice
Overall, supplementation with nicotinamide riboside, when comparing the relevant PK/PD relationship, indicates a 1,000-times difference in NAD response than does the latest healthy human data with NMN supplementation. Thorne's nicotinamide riboside malate (NRM) ingredient has one of the highest safety profiles in the NR market, and it can be used at higher doses, thus ensuring you will see results with your patients. Thorne’s NR supplement is also the subject of several ongoing clinical trials related to healthy aging, cognition, and human performance. These ongoing clinical studies will continue to produce significant safety and efficacy evidence and further support your protocol development needs. So, as we continue to see our understanding of NAD support supplementation change, as well as the landscape in which we provide safe and effective support changes, one thing has remained very stable – nicotinamide riboside is the most efficient way to increase the level of NAD in the body.
- Dr. Stephen Phipps, Chief Innovation Officer
