Indole-3-carbinol is a member of the class of sulfur-containing chemicals called glucosinolates, phytochemicals found in high amounts in cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. Indole-3- carbinol functions as an antioxidant, stimulates natural detoxification enzymes and supports normal hormone metabolism. † Furthermore, I-3-C supports the function of healthy breast and cervical cells. † In recent years, I-3-C has shown a promising ability to support prostate cell metabolism. †
In the stomach, indole 3-carbinol must be broken down into its active metabolite diindolylmethane, another indole compound that also has similar health benefits. Indole-3-carbinol supports healthy estrogen metabolism by promoting a healthy ratio of weak estrogens (2-hydroxyestone metabolites or 2-OHE) to strong estrogens (16 alpha-hydroxyestrone metabolites or 16 alpha-OHE) in favor of the weak, less potent estrogens. Indole-3- carbinol also induces phase II enzymes including glutathione S-transferase (GST). Cruciferous vegetables like broccoli and cauliflower offer protective sulforophane compounds known for their ability to induce protective detoxifying enzymes.
Adults take 1-2 capsules daily in divided doses with meals or as directed by a healthcare professional.
Female patients who are prone to headaches and continue to have hot flashes and night sweats on Estrogen replacement have found that if they take DIM (Indole-3-Carbinol / Diindolylmethane (DIM)complex) at the same time they take their Estradiol or Biest, they NO longer have hot flashes, sweats and headaches.
This may be due to I3C and DIM increasing C2 Hydroxylation of the estrogen in favor of C4 and C16 Hydroxylation which also decreases breast cancer risk.
If you are continuing to have these menopause symptoms while on Bio-Identical Estrogen therapy, try taking Indole 3 Carbinol.
Supplement Facts
Amount Per Serving
Serving Size 1 Vegetarian Capsule • Servings Per Container 60 each serving contains:
- Indole-3-Carbino 200 mg
- Proprietary Blend 100 mg
- Standardized broccoli extract (sprouts), Cauliflower (entire plant) and Brussel sprout (entire plant).
- Other ingredients: Hydroxypropyl methylcellulose (capsule), cellulose and vegetable stearate.
WARNING:
Women who are breastfeeding or pregnant should not take this product.
Keep this product out of the reach of children. Store in a cool, dry place.
SIDE EFFECTS:
No adverse effects have been reported. The conversion of I-3-C to its active metabolites requires stomach acid. Therefore, antacids, H2 blockers, and proton-pump inhibitors may impede its effectiveness.
